Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
I am here to speak for the countless animals dying across this planet because they have nowhere left to go. We cannot afford to be not heard. 我为这个行星上无数正在垂死的动物而演讲，因为它们几乎已经无处容身了。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
HOW MUCH: $2,050,000
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
He did several makeup tests to get the look that would so dramatically change Mr. Carell. “We were literally creating a new human being,” Mr. Corso said.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
上榜的商学院包括来自26个国家的商学院，其中美国有35家，英国有10家，中国有9家。中国人民大学商学院(Renmin University of China School of Business)的排名上升最快，从第43名升至第18名。法国的格勒诺布尔商学院(Grenoble Business School)排名第70名，土耳其的萨班哲大学管理商学院(Sabanci University School of Management)排名第99名，巴西的Coppead排名第100名。
“当我刚开始创业的时候，布鲁克林还是个替代选项；而现在，它已经成为一个优选地段了，”霍尔斯特德房地产公司(Halstead Property)的首席执行官黛安娜·M·拉米雷斯(Diane M. Ramirez)说，“我看到皇后区(Queens)正在朝这个方向发展,布朗克斯(Bronx)也不远了。”
The Man Who Knew, by Sebastian Mallaby, is the 12th winner of the ￡30,000 award, which goes to the “most compelling and enjoyable” title of the year.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Song “Chang’er”(Li Yugang and three Chinese astronauts)
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.
ACE2 as a potential therapeutic target for pandemic COVID-19
201212/212620.shtmlChina won the Robot World Cup Soccer 2013 against the Netherlands in a thrilling match that resulted in a 2-3 win for China.The Robot World Cup Soccer was held in Eindhoven, the Netherlands, which defended its Robot World Cup title of last year.
Diagnostic technologies for COVID-19: a review
自该学校的国际管理学硕士(International Master in Management)项目首次被纳入榜单以来，该学校的排名在过去两年上升31个位置。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
China's pension insurance balance of urban employees and urban and rural residents added up to four trillion, according to the Annual Report on Social Security Development 2015.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
“An employee stormed out in the middle of a meeting, without explanation.”
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Taken together, these events and strategic initiatives highlight the Chinese aerospace industry’s realization that, in order to become a globally competitive player, it will need depth as much as breadth. After getting their hands on both ends of the value chain—aircraft design and final assembly—the Chinese now understand that what will make or break their industry over the long term is what happens in the middle of the value chain, at the component and subsystem levels. And that is why China’s ambition to compete with Boeing and Airbus, as well as with GE and Rolls-Royce for aircraft engines, is now more credible than ever.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
China will "fasten the seat belt" and prevent any "acute outburst" of financial risks on the track for maintaining medium-high growth speed.
Antiviral drug discovery: broad-spectrum drugs from nature
Chinese manufacturers:Coming to the U.S.? Warren Buffett’s BYD says it is arriving in 2015 and Geely in 2016 but we’ve been hearing that someone was coming since at 2006. The refinement of Chinese cars is the issue. With more than 80 local automakers producing 524 different models in China, R&D money is spread too thinly to produce meaningful results.
Influenza neuraminidase: A druggable target for natural products
"There are always jobs," Challenger says. "Companies are always hiring. But the competition is much tougher."
Grains have fallen about 3 per cent.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
不过在这一通胡闹之余（主持人蒂娜?费举杯道：致这个美好的混乱之夜），本届金球奖(Golden Globes)颁奖典礼还是清醒地把多项重要大奖颁给了各个夺奖热门。戴维?罗素(David O. Russell)电影作品《美国骗局》(American Hustle) 揽入包括最佳喜剧片在内的三项金球奖，成为当晚最大赢家。历史剧情片《为奴十二年》(12 Years a Slave)虽在另外六个竞赛单元中失利，但最终斩获了最佳剧情片奖。
美国科学家Craig Bennett，Abigail Baird，Michael Miller，和George Wolford被授予搞笑神经科学奖，以奖励其在脑科学研究方面的贡献。他们的研究显示，利用复杂的设备加上简单的统计学方法，你几乎可以在任何地方得出有意义的脑活动研究结果——甚至是在一条死去的鱼身上也是如此！
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
The cemetery was found in the city of Kucha, which is located in present-day northwest China. Ten tombs were excavated, seven of which turned out to be large brick structures.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The online novel Once Upon A Time by Tang Qi was published in 2009. This year saw a series of adaptations of the novel, including a TV series, a film, a drama and a computer game.
Call Me by Your Name
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
继8月中旬贬值后，人民币在9月和10月有所上涨，但在11月再度走低，昨日人民币汇率收跌至三个月最疲弱水平，为1美元兑6.4082元人民币。“中国周边很多国家自10月份起经历了一些资本外流，中国也未能幸免，”深圳招商证券(China Merchants Securities)经济学家谢亚轩表示。“美元走强势必在一定程度上引发转投美元资产的行为。”
Argentina, the host nation's big rivals, are in with a great chance too. Any team featuring Lionel Messi is going to be in with a shout, but when you add to that the likes of Sergio Aguero, Gonzalo Higuain and Ezequiel Lavezzi, then it's a team with one of the best sets of attacking options in the tournament. Likewise, Uruguay's attacking trio of Luis Suarez, Edinson Cavani and Diegoi Forlan is about as potent as it can get, and is capable of scoring goals against any team in the world, although whethere the rest of their team is strong enough is open to debate.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Mila Kunis just keeps on raking in those sexy titles.
Inhibition of SARS coronavirus helicase by bismuth complexes
After laying low for months, Taylor made a spectacularly bold return with this new album.
Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.
Premiered on Jan 29, the drama received 7 points out of 10 on the country's popular review website Douban.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
It’s the time of the year for list making! This Youku video clip named the nine hottest lines on China’s web this year. The Yangtze Evening Post, an influential newspaper, is the original list compiler.
The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
7.Do not ask a policeman the best way to get to the West End or how to use an Oyster card. He wants to help, but he's from the West Midlands.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
11. “The Black Panthers: Vanguard of the Revolution” (Stanley Nelson)
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
n. 史诗，叙事诗 adj. 史诗的，叙事诗的，宏大的，
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
If 2017 was the year of fake news, 2018 is shaping up to be one of fake data. And just as fake news comes in many varieties — real news dubbed by the US president as fake, as well as nonsense gaining huge audiences on social media — so does fake data.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
If successful, Hurun estimates that Mr Wang’s net worth could soar past $50bn, making him one of the world’s 10 richest men.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
最佳迷你剧集/电影类编剧：D?V?蒂文森斯(D.V. DeVincentis)，《美国罪案故事：公诉辛普森》，“玛西亚，玛西亚，玛西亚” (The People v. O. J. Simpson: American Crime Story, "Marcia, Marcia, Marcia")
The continued, albeit slower growth in prices tracks with recent data showing real estate investment ticked upward in October and sales had registered barely any negative impact from the new restrictions.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Along with her friend Chloe, Max is out to uncover the truth behind the mysterious disappearance of fellow student Rachel Amber. With an indie-film feel and an eclectic soundtrack, Life Is Strange stands out from other games by blending the angst of being a teenage girl today with life-and-death situations, and the ability to rewind time. While this gameplay mechanic has been used in many games before, this take on time manipulation feels as unique as the American characters the French developer has created.
Other top ten foreign pictures were Transformers: The Last Knight, Dangal, Pirates of the Caribbean: Dead Men Tell No Tales, and Kong: Skull Island.
"Hard to believe so many doctors lied in the papers. Can patients still trust them to help us treat diseases?" wrote one Sina Weibo user.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
A moment of panic followed, before the teenager decided to take matters into his own hands and find a way out.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Zuckerberg also helped launch a lobbying group that is working toward immigration and education reform in the U.S called FWD.us.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
"They see some pretty awful things," she told the BBC. "But this is something that will stay with them for a long time."
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The standout is "Him," a tear-jerker about queer love and cultural intolerance that, in its understated way, is an LGBTQ civil rights anthem.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Lufax is the largest, a subsidiary of China’s Ping An Insurance, which is Lufax’s largest shareholder.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
瑞士洛桑国际管理发展学院(IMD)和西班牙Iese商学院(Iese Business School)稳坐英国《金融时报》两份高管教育榜单榜首。英国《金融时报》2017年高管教育排行榜开放招生课程和定制课程两份排名的头两名，均由这两所学校包揽。
Surveys indicate that a majority of women suffer or have suffered gender prejudice when looking for a job, because employers do not want to grant maternity leave. To avoid possible gender discrimination from employers as a result of their entitlement to maternity leave and increase their employment competitiveness, some female job seekers have reportedly chosen to get married and have their children before graduating from universities.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Amazon, Starbucks and Facebook have seen their brand values shoot up in 2016 compared with 2015. Amazon’s 59 per cent rise in value to $99bn and seventh place ranking, is partly due to its ability to create demand and not just satisfy it, according to Elspeth Cheung, head of BrandZ valuation at Millward Brown. She says Amazon’s one-hour delivery service has put pressure on other retailers to speed up delivery times while the online retailer’s move into logistics poses a threat to courier services UPS, FedEx and DHL.
然而，澳大利亚和西班牙学校表现不错。这两个国家分别有3所学校上榜，且排名均有上升。悉尼的麦考瑞大学管理学院(Macquarie Graduate School of Management)是澳大利亚排名最高的学府，排在第49位，而西班牙IE商学院(IE Business School)的排名上升4个位次，排在第8位，这是这所位于马德里的学校自2012年以来首次回到前10名。
Zhang Guoli to host 2014 Spring Festival Gala
A modular microarray imaging system for highly specific COVID-19 antibody testing
‘Law & Order: SVU’ This NBC ripped-from-the-soap-opera perils of Olivia (Mariska Hargitay) — psychopath rapist-stalker, tortured love affair, new baby — that took up so much air last season finally died down, and this season, the show’s 16th, the detectives got back to sex crimes à clef, including a Ray Rice-inspired episode about a star sportscaster who was seen on a surveillance camera punching the lights out of his wife.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
今年由美国电影学会的电影评审总监是Tom Pollock，担任电视剧评审总监的是Richard Frank。评审团的其他成员还包括Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin,来自知名大学的著作家，学者，公认的电影艺术家，还有像媒体NPR,Rolling Stone, TV Guide, 华盛顿邮报对于电视电影的评论家们。
That brought the balance of trade to $49.06bn, down about $4.3bn from November and coming in about $2.3bn lower than forecast.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Latest data from the US Treasury Department shows that India held securitie sworth $80 billion in September and further reduced its exposure to $77.5billion in October -- which is also a three-month low.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
That was in line with last month’s manufacturing PMIs, which showed an uptick in sector activity,
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Total Program Cost: $181,500 in either Philadelphia or San Francisco
The regulator said that “faced with a complex and volatile market environment,” funds had realised gains of only Rmb294.5bn in the first half, a drop of 42.3 per cent.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Matt Damon was named best actor in a comedy or musical motion picture for his role as a stranded astronaut in The Martian.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Equally, a three-week interning stint at PwC in the school summer holidays gave her the chance to sample life in a professional services firm. “I didn’t think I would get a place on [PwC’s programme] as I had no business experience,” she says.
Official data indicates a total of 81 feature length films, including 47 Chinese titles, surpassed the 100 million yuan box office threshold.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Turn your work in on time. If extra credit work is offered, do that too.
The banking industry has been experiencing a low profit growth period and will be for a long time, the National Business Daily reported, citing an expert. He said the banks' yearly profits growth reached 35 to 40 per cent in the past dozen years, but now the growth had slowed to less than 1 per cent, with some banks even recording a loss.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
And while you are at it, don't forget to celebrate the imperfections. While on a 10-day trek in the Himalayas, I learned that imperfections are beautiful too. The rough edges of the mountains, the heavy hail storms in the middle of the afternoon, were "inconvenient" but added to the beauty of the trek. I am acutely aware now that in my pursuit of perfection at work, I have often failed to recognize that imperfections are also a core part of our identity that needs to be preserved and not always changed.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
“见风使舵！”“谄媚迎合美国人！”官方入选名单一经宣布，负面评价如潮水般汹涌而来。电影节上影片使用英语对白的导演不在少数，包括了意大利的马提欧?加洛尼（Matteo Garrone）和保罗?索伦蒂诺（Paolo Sorrentino），希腊的欧格斯?兰斯莫斯，挪威的约阿希姆?提尔（Joachim Trier），甚至包括法国的纪洛姆?尼克乐（Guillaume Nicloux）。法国有着对英语威胁极其敏感的文化情结。有一个观点认为，戛纳应该是世界电影的天堂，而英语电影的天堂已经有了，就是好莱坞。但这有意义吗？在戛纳电影节上，除了法语或英语影片，其他影片都是双语字幕--这是个巨大的工程。
Total net profit for China’s commercial banks grew by 2.4 per cent last year, according to data from China’s bank regulator. Smaller banks saw increases in profit growth, while bigger banks slowed down.
Length-scale dependence of protein hydration-shell density
The data was released to encourage the adoption of stronger passwords. Mr Slain added:"As always, we hope that with more publicity about how risky it is to use weak passwords, more people will start taking simple steps to protect themselves by using stronger passwords and using different passwords for different websites."
10. 迪皮卡-帕度柯妮 1000万美元
Add your scores for questions one to nine to see how you score on the Negative Affectivity scale
The disclosure form also warns forex buyers that they are not allowed to exploit others’ exchange quotas. Previously, aggregating quotas from multiple individuals was a common technique that grey-market money changers used to obtain large sums of foreign exchange.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Now, Curry and the Golden State Warriors are right road of adding another accomplishment.
Watching Under the Skin again brought to mind another comparison: Orson Welles – the Welles who succeeded in creating a hoax martian invasion on the radio and who, in F for Fake (1975), got his partner Oja Kodar to walk around the streets in a miniskirt, secretly filming the lascivious expressions of the non-actor guys looking at her.
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