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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

potential
你的老板有望学会使用Twitter

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

I am here to speak for the countless animals dying across this planet because they have nowhere left to go. We cannot afford to be not heard. 我为这个行星上无数正在垂死的动物而演讲,因为它们几乎已经无处容身了。
拉娜·德雷《渴望生活》

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

HOW MUCH: $2,050,000

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

He did several makeup tests to get the look that would so dramatically change Mr. Carell. “We were literally creating a new human being,” Mr. Corso said.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 楼市“小阳春”背后的三重分化
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

上榜的商学院包括来自26个国家的商学院,其中美国有35家,英国有10家,中国有9家。中国人民大学商学院(Renmin University of China School of Business)的排名上升最快,从第43名升至第18名。法国的格勒诺布尔商学院(Grenoble Business School)排名第70名,土耳其的萨班哲大学管理商学院(Sabanci University School of Management)排名第99名,巴西的Coppead排名第100名。
“当我刚开始创业的时候,布鲁克林还是个替代选项;而现在,它已经成为一个优选地段了,”霍尔斯特德房地产公司(Halstead Property)的首席执行官黛安娜·M·拉米雷斯(Diane M. Ramirez)说,“我看到皇后区(Queens)正在朝这个方向发展,布朗克斯(Bronx)也不远了。”
portion
The Man Who Knew, by Sebastian Mallaby, is the 12th winner of the £30,000 award, which goes to the “most compelling and enjoyable” title of the year.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

8月7日
adj. 剧烈的,严重的,严峻的,严厉的,严格的
特斯拉的积压订单达到2.26亿美元。到2014年之前,特斯拉的生产速度大约为每周1000台,也就是说这些订单需要30周才能消化完。
所以,是的,我认为他们应该果断垫底甚至交易伊巴卡以换取更多的价值,尽管这变脸来得有点快。唉,天啊,这支队伍实在太诡异了。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

可以想象,2016年油价将从当前不到40美元的水平上反弹。沙特或许会尝试减产,伊拉克可能会爆发更多冲突,恐怖主义分子可能会攻击一些重要目标,比如沙特拉斯坦努拉和阿巴奇克的石油终端。一切皆有可能,有些事情发生的可能性更大一些。但问题在于,油价反弹的幅度将有多大?

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Song “Chang’er”(Li Yugang and three Chinese astronauts)

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

['depjuti]
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 红星美凯龙抵制天猫双11活动
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

请接受我诚挚的新年祝福,顺祝身体健康。
201212/212620.shtmlChina won the Robot World Cup Soccer 2013 against the Netherlands in a thrilling match that resulted in a 2-3 win for China.The Robot World Cup Soccer was held in Eindhoven, the Netherlands, which defended its Robot World Cup title of last year.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 新华社:稳定房地产 调控要从严
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Anjli Raval
自该学校的国际管理学硕士(International Master in Management)项目首次被纳入榜单以来,该学校的排名在过去两年上升31个位置。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

immunity
人类活动造成的这些气体及其他气体的增加,导致地球温度与前工业化时代相比,上升了大约1.5华氏度(约合0.8摄氏度),造成全球陆冰融化。海平面上升的速度似乎正在加快,热浪和暴雨天气越来越多。
《泰晤士高等教育》专刊的编辑菲尔·巴蒂说道:“中国采取了强有力的政策,且背后又有雄厚的资金支持,才能打造这些世界一流的大学。2015年,中国就宣布将实施‘卓越计划',计划在2020年之前打造六所可以跻身世界一流行列的高校。”
拉动你的行李箱,带上你的耐心。假日航空旅行季节即将到来,如果你想有趟轻松愉快的旅程,那么对美国人最好的建议就是选择飞往西部。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

China's pension insurance balance of urban employees and urban and rural residents added up to four trillion, according to the Annual Report on Social Security Development 2015.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

10月份的读数较9月份回落0.8个百分点,其中主要追踪大型国有企业的生产指数回落1.3个百分点,降至53.4。新订单指数回落1.9个百分点,降至52.9。
“An employee stormed out in the middle of a meeting, without explanation.”

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Taken together, these events and strategic initiatives highlight the Chinese aerospace industry’s realization that, in order to become a globally competitive player, it will need depth as much as breadth. After getting their hands on both ends of the value chain—aircraft design and final assembly—the Chinese now understand that what will make or break their industry over the long term is what happens in the middle of the value chain, at the component and subsystem levels. And that is why China’s ambition to compete with Boeing and Airbus, as well as with GE and Rolls-Royce for aircraft engines, is now more credible than ever.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

China will "fasten the seat belt" and prevent any "acute outburst" of financial risks on the track for maintaining medium-high growth speed.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

从2004年起,过去120年里的现代或当代艺术家们创作的10件作品在拍卖会上共卖出1亿多美元。而更早期绘画大师的作品价格则是稳中有跌。最近几周,这一趋势非常明显,伦敦的拍卖公司努力为自己的最新一批18世纪前绘画大师作品寻找买家。与近些年的情况一样,其中几乎没有名作。
Chinese manufacturers:Coming to the U.S.? Warren Buffett’s BYD says it is arriving in 2015 and Geely in 2016 but we’ve been hearing that someone was coming since at 2006. The refinement of Chinese cars is the issue. With more than 80 local automakers producing 524 different models in China, R&D money is spread too thinly to produce meaningful results.
在这个被大型地产开发商主宰的市场,结构性挑战通常成为抑制欧美大型资产管理公司的因素。
con共同,duct引导-引导大家的行为举止

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

教育企业高管的薪酬均值倒数第一,刚过280万元,约为金融业高管薪酬的1/10。
['p?li?]
"There are always jobs," Challenger says. "Companies are always hiring. But the competition is much tougher."
v. 屈从,死
Grains have fallen about 3 per cent.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

不过在这一通胡闹之余(主持人蒂娜?费举杯道:致这个美好的混乱之夜),本届金球奖(Golden Globes)颁奖典礼还是清醒地把多项重要大奖颁给了各个夺奖热门。戴维?罗素(David O. Russell)电影作品《美国骗局》(American Hustle) 揽入包括最佳喜剧片在内的三项金球奖,成为当晚最大赢家。历史剧情片《为奴十二年》(12 Years a Slave)虽在另外六个竞赛单元中失利,但最终斩获了最佳剧情片奖。
美国科学家Craig Bennett,Abigail Baird,Michael Miller,和George Wolford被授予搞笑神经科学奖,以奖励其在脑科学研究方面的贡献。他们的研究显示,利用复杂的设备加上简单的统计学方法,你几乎可以在任何地方得出有意义的脑活动研究结果——甚至是在一条死去的鱼身上也是如此!

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

加拿大人:到了英国,你们恐怕会一次又一次地被人误认为是美国人,还会因为那些和你们毫无关联的事情而备受指责。除非你能想出一种简便快速的办法,让人一眼就能看出你是加拿大人(在衣领上夹一朵花?穿马鞍鞋?戴枫叶图案的眼罩?)要不然你也就只能慢慢习惯,不再抱怨了。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

The cemetery was found in the city of Kucha, which is located in present-day northwest China. Ten tombs were excavated, seven of which turned out to be large brick structures.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The online novel Once Upon A Time by Tang Qi was published in 2009. This year saw a series of adaptations of the novel, including a TV series, a film, a drama and a computer game.
美国总统奥巴马以每年40万美元的收入高居榜首,同时还拥有5万美元的免税账目。国会最近一次给美国总统加薪是在2001年。
我是否工作太辛苦了?花时间重新调整一下,花时间做令你愉快的事情是非常重要的。必要时释放你的欲望,从工作或学习压力中解脱出来,给自己时间去自由呼吸,即便一次只有几分的时间。
Call Me by Your Name

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

继8月中旬贬值后,人民币在9月和10月有所上涨,但在11月再度走低,昨日人民币汇率收跌至三个月最疲弱水平,为1美元兑6.4082元人民币。“中国周边很多国家自10月份起经历了一些资本外流,中国也未能幸免,”深圳招商证券(China Merchants Securities)经济学家谢亚轩表示。“美元走强势必在一定程度上引发转投美元资产的行为。”
这个墓地在如今中国西北部的库车县被找到。已经有10个坟墓被挖掘出土,其中7个是大型的砖石结构。
Argentina, the host nation's big rivals, are in with a great chance too. Any team featuring Lionel Messi is going to be in with a shout, but when you add to that the likes of Sergio Aguero, Gonzalo Higuain and Ezequiel Lavezzi, then it's a team with one of the best sets of attacking options in the tournament. Likewise, Uruguay's attacking trio of Luis Suarez, Edinson Cavani and Diegoi Forlan is about as potent as it can get, and is capable of scoring goals against any team in the world, although whethere the rest of their team is strong enough is open to debate.
特朗普会发动美中贸易战吗?

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Mila Kunis just keeps on raking in those sexy titles.
时间:2010-09-19 编辑:beck

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

[k?:]
After laying low for months, Taylor made a spectacularly bold return with this new album.
11 August
Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.
Premiered on Jan 29, the drama received 7 points out of 10 on the country's popular review website Douban.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

It’s the time of the year for list making! This Youku video clip named the nine hottest lines on China’s web this year. The Yangtze Evening Post, an influential newspaper, is the original list compiler.
n. 码,密码,法规,准则
The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

['pr?ut?k?l]
7.Do not ask a policeman the best way to get to the West End or how to use an Oyster card. He wants to help, but he's from the West Midlands.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 一套二手房 平均看15次成交
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 小业主“抱团”护价注定较难成功
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

虽然有17%的毕业生将创业列为同等最重要的原因,但他们中只有2%的人将此视为自己唯一主要的目标。然而,学员身上的创业精神明显在增强,超过四分之一的毕业生(26%)称在就读EMBA期间或毕业后创办了自己的公司。
11. “The Black Panthers: Vanguard of the Revolution” (Stanley Nelson)
8.表达感激之情

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

【中文译文】
n. 史诗,叙事诗 adj. 史诗的,叙事诗的,宏大的,
上月越南主席张晋创对中国进行国访,会见中国主席习近平。但中越双方并未就跨境贸易达成一致。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

If 2017 was the year of fake news, 2018 is shaping up to be one of fake data. And just as fake news comes in many varieties — real news dubbed by the US president as fake, as well as nonsense gaining huge audiences on social media — so does fake data.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

If successful, Hurun estimates that Mr Wang’s net worth could soar past $50bn, making him one of the world’s 10 richest men.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

最佳迷你剧集/电影类编剧:D?V?蒂文森斯(D.V. DeVincentis),《美国罪案故事:公诉辛普森》,“玛西亚,玛西亚,玛西亚” (The People v. O. J. Simpson: American Crime Story, "Marcia, Marcia, Marcia")
The continued, albeit slower growth in prices tracks with recent data showing real estate investment ticked upward in October and sales had registered barely any negative impact from the new restrictions.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Along with her friend Chloe, Max is out to uncover the truth behind the mysterious disappearance of fellow student Rachel Amber. With an indie-film feel and an eclectic soundtrack, Life Is Strange stands out from other games by blending the angst of being a teenage girl today with life-and-death situations, and the ability to rewind time. While this gameplay mechanic has been used in many games before, this take on time manipulation feels as unique as the American characters the French developer has created.
Other top ten foreign pictures were Transformers: The Last Knight, Dangal, Pirates of the Caribbean: Dead Men Tell No Tales, and Kong: Skull Island.
但当格雷泽给我们带来《皮囊之下》,这部经过他长期酝酿的,由荷兰作家米歇尔·法柏的科幻小说改编的电影时,真是让人惊叹:欢快,不安,大胆。斯嘉丽扮演的外星人藏于人类的皮囊里,穿梭在格拉斯哥街道和商场,不亚于一位一线明星。现实生活中的路人在镜头中完美的展现,而隐身的约翰森面无表情的估算着三个地球人可被利用的热量值。接着演员带着被色诱的人类离开人群,来到她自己的地方:一个神秘的黑暗的洞穴中。在这里,情色恍惚间,人类贡献自己的肉体,被囚禁,被养殖成为食物,谁知道呢,又或许是人类的灵魂。
"Hard to believe so many doctors lied in the papers. Can patients still trust them to help us treat diseases?" wrote one Sina Weibo user.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

A moment of panic followed, before the teenager decided to take matters into his own hands and find a way out.
这句简练、言之有物、几乎可称之为妙语的话提醒我们,即便接下来的奖项都相当雷人,还是有人能够做到直白的。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Zuckerberg also helped launch a lobbying group that is working toward immigration and education reform in the U.S called FWD.us.
1=不全是

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

"They see some pretty awful things," she told the BBC. "But this is something that will stay with them for a long time."

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

办好公平优质教育。
如果你没听过这句话,你去年绝对没上过中文网。这句简单的话是留在魔兽BBS上的,不知道什么原因——有说法是有网络公司是幕后推手——这句话吸引了710万人点击,在发布后24小时内产生了30万条评论。
去年,由于俄罗斯经济陷入衰退,总统普京的工资因此缩减10%,但在此之前,普京2014年4月薪资增长逾两倍,约970万卢布。
The standout is "Him," a tear-jerker about queer love and cultural intolerance that, in its understated way, is an LGBTQ civil rights anthem.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

com共同,miss=mit送-共同送东西到指定处-委托com共同,mission(n 使命,任务)-受了别人的委托,说明你得到了别人的信任,所以这是一种使命。
Lufax is the largest, a subsidiary of China’s Ping An Insurance, which is Lufax’s largest shareholder.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

在日本博览会上,我们非常荣幸地采访到了虚渊玄,还有Nitro+社长Takaki Kosaka。让我们开始吧。
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
国内航空统计公司飞常准发布的最新报告显示,我国主要机场的准点率仍然远未让人满意。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 深圳:旧厂房变身创新型产城社区
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

3.3M公司
瑞士洛桑国际管理发展学院(IMD)和西班牙Iese商学院(Iese Business School)稳坐英国《金融时报》两份高管教育榜单榜首。英国《金融时报》2017年高管教育排行榜开放招生课程和定制课程两份排名的头两名,均由这两所学校包揽。
Surveys indicate that a majority of women suffer or have suffered gender prejudice when looking for a job, because employers do not want to grant maternity leave. To avoid possible gender discrimination from employers as a result of their entitlement to maternity leave and increase their employment competitiveness, some female job seekers have reportedly chosen to get married and have their children before graduating from universities.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

“D型人格”最先由荷兰蒂尔堡大学的心理学家Johan Denollet提出。他还设计了一个测试,帮助人们认识自己是否具有D型人格特征。
其次,尽管人们还守着老的观念,现实却已经发生了变化:供应链管理——也就是确保货物以尽可能低的价格和尽可能高的效率到达目的地——已经成为一项高科技、高风险的行业了。它要求从业者“硬件能力”和“软件能力”缺一不可,而能达到这种要求的人才实在很少。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 节水型卫浴成为市场“香饽饽”
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Amazon, Starbucks and Facebook have seen their brand values shoot up in 2016 compared with 2015. Amazon’s 59 per cent rise in value to $99bn and seventh place ranking, is partly due to its ability to create demand and not just satisfy it, according to Elspeth Cheung, head of BrandZ valuation at Millward Brown. She says Amazon’s one-hour delivery service has put pressure on other retailers to speed up delivery times while the online retailer’s move into logistics poses a threat to courier services UPS, FedEx and DHL.
然而,澳大利亚和西班牙学校表现不错。这两个国家分别有3所学校上榜,且排名均有上升。悉尼的麦考瑞大学管理学院(Macquarie Graduate School of Management)是澳大利亚排名最高的学府,排在第49位,而西班牙IE商学院(IE Business School)的排名上升4个位次,排在第8位,这是这所位于马德里的学校自2012年以来首次回到前10名。
Zhang Guoli to host 2014 Spring Festival Gala

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

高位且不断上升的美国利率可能很快成为新兴市场危机的驱动因素:此类条件可能导致新兴市场借贷成本升高,还有资本外流以及金融部门冒险意愿下降。
‘Law & Order: SVU’ This NBC ripped-from-the-soap-opera perils of Olivia (Mariska Hargitay) — psychopath rapist-stalker, tortured love affair, new baby — that took up so much air last season finally died down, and this season, the show’s 16th, the detectives got back to sex crimes à clef, including a Ray Rice-inspired episode about a star sportscaster who was seen on a surveillance camera punching the lights out of his wife.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

今年由美国电影学会的电影评审总监是Tom Pollock,担任电视剧评审总监的是Richard Frank。评审团的其他成员还包括Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin,来自知名大学的著作家,学者,公认的电影艺术家,还有像媒体NPR,Rolling Stone, TV Guide, 华盛顿邮报对于电视电影的评论家们。
That brought the balance of trade to $49.06bn, down about $4.3bn from November and coming in about $2.3bn lower than forecast.
紧随其后的是亚马逊创始人杰夫·贝索斯,这是他第一次排名第三,由于亚马逊股值飙升,他的资产达到了728亿美元。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Latest data from the US Treasury Department shows that India held securitie sworth $80 billion in September and further reduced its exposure to $77.5billion in October -- which is also a three-month low.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

不会。华尔街策略师预测美国政府的10年期借贷成本将在未来一年攀升至3%以上,这话就像尴尬的办公室聚会一样是圣诞节那段时间的固定节目。鉴于美联储退出量化宽松和美国减税,今年的预测看起来更有可能实现。然而,压低通胀和长期债券收益率的长期重大因素依然存在,并且仍然被低估。2018年美联储将至少加息三次,但10年期收益率不会突破3%。
That was in line with last month’s manufacturing PMIs, which showed an uptick in sector activity,

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Total Program Cost: $181,500 in either Philadelphia or San Francisco
The regulator said that “faced with a complex and volatile market environment,” funds had realised gains of only Rmb294.5bn in the first half, a drop of 42.3 per cent.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

1月份出口同比下滑6.6%至1.14万亿元人民币,而此前在去年12月份则曾增长2.3%。经济学家原本预计会增长3.6%。这是自去年7月下滑8.9%以来,出口出现的最大跌幅。
创业者都是行动者和颠覆者。他们不能去分析每一个细节,否则他们将寸步难行。初创公司没有拖延的资本。创业是一个全天候、无休假的职业,创业者必须具备持久不变的前进动力。迈出每一步的时候进行简单的评估,然后继续前进。相信自己的直觉。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

本田执行副总裁里克o斯考斯特克在一项声明中表示:“我们已经解决了这一问题。本田已经在早期预警报告中采取了一些重大举措来解决过去的缺陷问题,现在我们将更进一步,加强这些举措。我们将继续与国家公路交通安全管理局充分合作,提高透明度,改进报告工作。”
有人会认为卡莉·西蒙演唱的《海底城》的主题曲最好听。他们可能有自己的理由,可能是因为这是"邦德电影中最好听的歌曲"。曲调欢快、充满吸引力、浪漫抒情,卡莉西蒙的演唱打动人心。但是这些对詹姆斯·邦德、他的冒险旅程、他的来历甚至他的电影没有任何特殊引导作用。尽管《没人做得更好》被认为是一首好歌,但是由于上述原因它并没能进入榜单前五名。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 一二线城市购房标准不断升级
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Matt Damon was named best actor in a comedy or musical motion picture for his role as a stranded astronaut in The Martian.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

以美元计,上个月进口下跌了18.8%,跌至1141.9亿美元,跌幅超过了去年12月的7.6%,也超过了下跌3.6%的预期。
Equally, a three-week interning stint at PwC in the school summer holidays gave her the chance to sample life in a professional services firm. “I didn’t think I would get a place on [PwC’s programme] as I had no business experience,” she says.
Official data indicates a total of 81 feature length films, including 47 Chinese titles, surpassed the 100 million yuan box office threshold.
其中有铁环的那一个是在江苏西部的仪征市发现的。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

《华胥引》

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Turn your work in on time. If extra credit work is offered, do that too.
The banking industry has been experiencing a low profit growth period and will be for a long time, the National Business Daily reported, citing an expert. He said the banks' yearly profits growth reached 35 to 40 per cent in the past dozen years, but now the growth had slowed to less than 1 per cent, with some banks even recording a loss.
如果此时打断老师讲课不太合适,你可以快速记下自己的问题,以免忘记,之后再问老师。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

定义自己
And while you are at it, don't forget to celebrate the imperfections. While on a 10-day trek in the Himalayas, I learned that imperfections are beautiful too. The rough edges of the mountains, the heavy hail storms in the middle of the afternoon, were "inconvenient" but added to the beauty of the trek. I am acutely aware now that in my pursuit of perfection at work, I have often failed to recognize that imperfections are also a core part of our identity that needs to be preserved and not always changed.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

然而,《秦时明月丽人心》并不能让更喜欢真实历史而非虚构故事的观众满意,该剧豆瓣评分仅为4.9分。
时间:2010-01-26 编辑:vicki

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

可口可乐表示,中国消费放缓打击了销售额,而较为疲弱的需求正迫使其降低库存。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

中国政策制定者的任何开始减持国内巨额储备的决定,都将对市场产生巨大影响。
“见风使舵!”“谄媚迎合美国人!”官方入选名单一经宣布,负面评价如潮水般汹涌而来。电影节上影片使用英语对白的导演不在少数,包括了意大利的马提欧?加洛尼(Matteo Garrone)和保罗?索伦蒂诺(Paolo Sorrentino),希腊的欧格斯?兰斯莫斯,挪威的约阿希姆?提尔(Joachim Trier),甚至包括法国的纪洛姆?尼克乐(Guillaume Nicloux)。法国有着对英语威胁极其敏感的文化情结。有一个观点认为,戛纳应该是世界电影的天堂,而英语电影的天堂已经有了,就是好莱坞。但这有意义吗?在戛纳电影节上,除了法语或英语影片,其他影片都是双语字幕--这是个巨大的工程。
Total net profit for China’s commercial banks grew by 2.4 per cent last year, according to data from China’s bank regulator. Smaller banks saw increases in profit growth, while bigger banks slowed down.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

The data was released to encourage the adoption of stronger passwords. Mr Slain added:"As always, we hope that with more publicity about how risky it is to use weak passwords, more people will start taking simple steps to protect themselves by using stronger passwords and using different passwords for different websites."
10. 迪皮卡-帕度柯妮 1000万美元
Add your scores for questions one to nine to see how you score on the Negative Affectivity scale
The disclosure form also warns forex buyers that they are not allowed to exploit others’ exchange quotas. Previously, aggregating quotas from multiple individuals was a common technique that grey-market money changers used to obtain large sums of foreign exchange.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

2016年,高管薪酬均值达709万元,同比增长8%,跑赢了我国国内生产总值6.7%和人均可支配收入6.3%的增速。
这次奠基之战借鉴了查克·温柏和拳王阿里的比赛,这个无名小卒温柏成了在阿里的职业生涯中击倒过他的区区4人之一。和电影里一样,温柏与阿里打了15回合,尽管他看起来(感觉也)像被卡车撞过。虽然他和洛奇最后都被对手技术性击倒,但温柏胜在启发了史泰龙塑造这个了不起的角色。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Now, Curry and the Golden State Warriors are right road of adding another accomplishment.
Watching Under the Skin again brought to mind another comparison: Orson Welles – the Welles who succeeded in creating a hoax martian invasion on the radio and who, in F for Fake (1975), got his partner Oja Kodar to walk around the streets in a miniskirt, secretly filming the lascivious expressions of the non-actor guys looking at her.
据《21世纪经济报道》称,广东去年的GDP增速为7.5%。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 前三季度龙江关停50家家具企业
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